E-ISSN: 2651-3153
The Results of Postoperative Chemoradiotheapy in Gastric Carcinoma Patients: Bulent Ecevit University Experience
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Original Article
VOLUME: 30 ISSUE: 3
P: 139-145
December 2014

The Results of Postoperative Chemoradiotheapy in Gastric Carcinoma Patients: Bulent Ecevit University Experience

Eur Arc Med Res 2014;30(3):139-145
DOI: 10.5222/otd.2014.139
Bekir Hakan Bakkal 1
Özlem Elmas 1
Fatma Ayça Gültekin 2
Hüseyin Engin 3
Cemil Bilir 3
Yasemin Bakkal Temi 3
1. Bülent Ecevit Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı
2. Bülent Ecevit Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalı
3. Bülent Ecevit Üniversitesi Tıp Fakültesi Tıbbi Onkoloji Bilim Dalı
No information available.
No information available
Received Date: 09.03.2014
Accepted Date: 22.07.2014
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ABSTRACT

Objective:

The treatment results of postopeative chemoradiotherapy in patients with gastric carcinoma were evaluated.

Material and Methods:

A total of 77 patients with gastric carcinoma, treated with postoperative chemoradiotherapy between 2007-2011, were evaluated retrospectively. Chemoradiotherapy was applied in accordance with the Integroup-0116 study protocol. Total 45 Gy radiotherapy was delivered to the gastric bed and regional lymphatic nodes and 50.4 Gy was given to patients with positive surgical margins after 3-dimensional conformal planning.

Results:

Forty-six of the patients were male (59.7 %), and 31 of the patients were female (40.3 %) with a median age of 59 (31-78). Median overall survival and disease-fee survival were 28.3, and 21 months, respectively. The 3-year overall and disease-free survival rates were 43.8 % and 41.7 %, respectively. Locoregional recurrence was detected in 10 (13 %), distant metastasis was detected in 22 (28.6 %) and both locoregional and distant metastasis were detected in 3 (3.9 %) of patients. During chemoradiotherapy grade 1-2 hematological toxicity was seen in 23 (30 %) patients, grade 3-4 hematological toxicity in 46 (59.7 %) patients, grade 1-2 gastrointestinal toxicity in 30 (39 %) patients, and grade 3-4 gastrointestinal toxicity in 11 (14.3 %) patients. While in the univariate analysis lymph node stage and percentage of positive lymph nodes were found to be prognostic factors for overall and disease-free survival, in the multivariate analysis type of lymph node dissection and percentage of positive lymph nodes were found to be prognostic factors that are correlated with overall and disease-free survival.

Conclusion:

Chemoradiotherapy improved loco-regional control rather than reduction of distant metastases. Acute especially hematologic side effects were commonly observed.