Very recently, a new coronavirus causing a serious, atypical pneumonia cluster that was life-threatening in humans was discovered in December 2019. The virus detected in China spread to 188 countries/regions all over the world in a short period of six months, and it was declared by the World Health Organization to cause pandemics. In Coronavirus Disease-2019 (COVID-19) , the main route of transmission is directly from person-to-person transmission by droplets and contact. In the reported publications, the disease related to Severe Acute Respiratory Syndrome-coronavirus-2 is more common in adults and causes a serious life-threatening disease, especially in the elderly. It is observed that it causes milder clinical presentation in children than adults. Fever and cough are also the most common symptoms in children. In the pandemic course, the department of pediatrics started the training, planning and preparation process before the acceptance of positive patients under the leadership of the Ministry of Health’s constantly updated guide and the established multidisciplinary science committee of our hospital. The treatment of COVID-19 positive pediatric patients has been carried out for most up-to-date and successful manner. The protection both of our healthcare personnel and other pediatric patients who had to use same health care facility during the pandemic course was provided within the framework of the taken infection control measures. While applying the current scientific data and the guide of the Ministry of Health, it was aimed to emphasize that it is important to make decisions in accordance with the dynamics of the process, organized with team spirit.