Case report
Signet Ring Basal Cell Carcinoma: An Extraordinary Case
1University of Health Sciences Turkey, Prof. Dr. Cemil Taşcıoğlu City Hospital, Clinic of Pathology, İstanbul, Turkey
Eur Arch Med Res 2022; 38(3): 230-232 DOI: 10.4274/eamr.galenos.2022.87441
Abstract
Basal cell carcinomas (BCCs) are slow-growing, locally agressive tumors arising from interfollicular epidermis and/or hair follicle. Here, a 74 year old man presented with an irregular nodule 2,5x2 cm in size on the left ala of nose for 3 years. On light microscopy the signet ring cell configuration was observed among neoplastic cells focally (in some areas). The most prominent feature was cells containing large eosinophilic, pink, eccentric intracytoplasmic inclusions which compress the nuclei to the cell border. The cell inclusions did not stain with PAS and alcian blue pH 2,5. Tumor cells were positive for Ber-EP4 but negative for S-100.
Keywords: Signet ring cell, basal cell carcinoma, dermatopathology