Abstract
Objective: Overactive bladder (OAB) may be interrelated with chronic inflammation. The aim of this study was to assess the role of neutrophil-lymphocyte ratio (NLR) levels in men and women with OAB symptoms.
Methods: Between January 2017 and February 2018, a total of 157 subjects (77 OAB patients and 80 controls) were included in the study. The subjects divided into two groups. Group 1=OAB patients and group 2=normal controls. Patients with active urinary tract infections, previous pelvic surgery or neurogenic patients were excluded. The enrolled both patients and control group were questioned using the 8-item OAB questionnaire (OAB-v8) complete blood count and serum C-reactive protein (CRP) levels were measured in the first visit.
Results: The mean NLR was 1.73±0.67 in patients and 1.48±0.75 in control groups (p<0.001). The NLR and CRP levels were both statistically significant higher in OAB patient group (p=0.03 for CRP and p=0.001 for NLR). There was positive correlation between OAB-v8 scores and NLR (p<0.001, r=0.215)
Conclusion: High serum NLR levels were observed in OAB patients. Our results support the association between chronic inflammations of the bladder in OAB patients.