Scabies, a globally prevalent parasitic infestation caused by Sarcoptes scabiei hominis, presents significant public health challenges, particularly in underdeveloped regions. Characterized by intense itching and distinctive rash patterns, scabies infestation requires prompt and accurate diagnosis to prevent outbreaks and additional health and economic burdens. The epidemiology of scabies underscores its high prevalence, particularly in conditions of overcrowding and poor hygiene, with an estimated 300 million cases annually worldwide. Transmission primarily occurs through prolonged skin-to-skin contact, and the risk is exacerbated in crowded living conditions and institutional settings. Clinical manifestations vary, with classic signs including burrows and intense nocturnal itching, and complications such as bacterial infections frequently arising. Diagnostic approaches range from microscopic examination of skin scrapings to non-invasive techniques like dermatoscopy and ultraviolet fluorescence. Effective management necessitates comprehensive treatment strategies, including the use of topical permethrin and oral ivermectin, emphasizing the need to treat all close contacts to curb reinfestation. Awareness and adherence to treatment protocols, alongside preventive measures, are crucial for controlling scabies outbreaks, reducing its public health impact, and improving the quality of life of affected individuals. This review highlights the importance of early detection, effective treatment, and public health strategies in managing scabies infestations, underscoring the need for increased awareness and action to address this neglected disease.