Novel technological developments are commonly used in oncology practice. The novel approach-es contribute to oncologist for screening, diagnosis, treatment, and follow-up periods. Genetic-based tests and liquid biopsies are well-known novel diagnostic techniques especially in breast and lung cancers. Targeted therapies, immune checkpoint inhibitors, invasive treatment modalities, and radioligand therapies are well-known advances in the treatment of cancer. These novel modalities in treatment are dependent on specific conditions especially mutations and receptor status in different cancer types. In this topic, we summarized the new technological advances in screening, diagnosis, treatment, and follow-up practices.