To present a unique case of rapid recurrence of glioblastoma after 12 days despite gross total resection. Glioblastomas are highly mortal and aggressive tumors. Despite advancements in therapy, gross total resection, radiotherapy, and chemotherapy, the recurrence rate is high and overall survival is short. We report a unique case of a patient with recurrence of glioblastoma in just 12 days despite gross total resection, which has not been previously reported in the literature. A 65-year-old woman complained of headaches and disturbance of speech for three days. On magnetic resonance imaging (MRI), a 5x4.5 cm diffuse contrast-enhanced mass lesion was detected. The patient underwent elective surgery in which the lesion was completely removed. Postoperative MRI scans revealed that the tumor was completely removed. She was released from the hospital on her postoperative 6th day. On the postoperative 12th day the patient was brought to our hospital with seizures and somnolence. On radiological images, a mass lesion in the same surgical area was detected. She underwent surgery in which the recurrent mass lesion was completely removed. Biopsy results correlated with those of the previous surgery. The reason why glioblastomas are such mortal tumors is their high recurrence rate. Overall recurrence occurs between 32-36 weeks after surgery. Serial neuroimaging should be performed to monitor potential relapse. Early recurrence before 3 months is very rare. A case like ours in which the tumor re-occurred just 12 days after total resection shows that there is still research to be done to understand the recurrence characteristics of glioblastoma.