INTRODUCTIONDecubitus ulcers, also called bedsores or pressure ulcers, are defined as skin and soft tissue injuries caused by sustained or prolonged pressure on the skin. Staphylococcus aureus (S. aureus) one of the most frequently isolated bacteria in patients with decubitus ulcer infection. In our study, we aimed to retrospectively determine the antimicrobial susceptibility profile of S. aureus strains isolated from wound swab cultures of patients hospitalized in various wards. METHODSWe examined wound swab cultures obtained from patients with clinical signs of decubitus ulcer infection during inpatient treatment in different wards with various diagnoses between January 2009 and October 2019. In these samples, antimicrobial susceptibility profile data of 132 S. aureus strains belonging to 132 different patients who were considered clinically significant were included in our study. RESULTSAmong all specimens, 132 (13.83%) S. aureus positivity cases were included in our study. The MRSA rate was 43.85% (24/56) in male patients and 57.14% (32/56) in female patients with decubitus ulcer infection. Of the S. aureus strains, 42.42% (56/132) were methicillin-resistant (MRSA) and 57.58% (76/132) were methicillin-susceptible (MSSA). Linezolid was found to be the most effective antibiotic among MRSA strains, whereas all MSSA strains were susceptible to Amoxicillin+Clavulanic acid, Rifampicin and Cefoxitin.DISCUSSION AND CONCLUSIONIt should be kept in mind that antimicrobial resistant strains such as MRSA may be encountered in half of S. aureus infections and may complicate treatment options. We concluded that these infections and antimicrobial resistance profiles should be routinely monitored.