Objective: We aimed to evaluate the susceptibility of patients with vocal cord nodules to psychoticism, extraversion, or neuroticism from the normal healthy population using the Eysenck’s Personality inventory.

Methods: A study cohort consisting of patients followed up with vocal cord nodules and age- and gender-matched healthy controls was asked to answer the questions in the Eysenck’s Personality inventory in a quiet and calm environment. The data were then evaluated and scored by the clinical psychologist, and personality profiles were determined.

Results: Eighty-six subjects (43 patients-43 controls) were included in the study. There was no significant difference between the groups in terms of mean scores of psychoticism (p=0.88) and extraversion (p=0.376), whereas the mean scores of neuroticism (p=0.027) and lie (p<0.01) were significantly different.

Conclusion: Although it is frequently encountered in daily practice, the personality characteristics of patients with vocal cord nodules are easily missed. However, determining this condition and therapy in this area may positively affect the treatment of the disease and may help to establish appropriate behavioral patterns to prevent recurrence.