Castleman’s disease (CD), also known as angiofollicular lymph node hyperplasia, is an uncommon, benign B-cell lymphoproliferative disorder. Adrenal CD is an extremely rare lesion of the adrenal gland that mimics other adrenal neoplasms reported only in a few cases in the literature. We presented a large-sized right adrenal CD, which was found incidentally in a 46-year-old male patient during the evaluation for coronavirus disease-2019 pneumonia. Although imaging features overlap with other hypervascular adrenal neoplasms, CD should also be considered in the differential diagnosis of the adrenal masses, particularly when it is relatively well defined with homogenous attenuation and enhancement despite its large size.