The relationships between science and technology have been disputed for almost a century now. As they appear to accelerate each other, the major effect of the technological innovation on ge-netic medicine has been mainly observed following the completion of the Human Genome Project. Genetic medicine, also known as medical genetics, currently focuses on many aspects of medicine including genomic analyses and clinical services, such as genetic counseling, diagnosis, and man-agement of genetic and hereditary disorders or genetic aspects and management of neoplastic diseases. This review provides an overview of the history of genetic medicine and an insight to the current application of genomic technology into clinical practice.