In this section, we aimed to share the experience of infectious diseases and clinical microbiology clinic during the Coronavirus Disease-2019 outbreak. The processes experienced in the first trimester from the beginning of the outbreak were evaluated. Our contribution to the fast, flexible and strong response to the epidemic in the institutional structure of our hospital was emphasized. The 3-month experiences of other countries shed light on us in the diagnosis and treatment of this disease, which was originally new to all of us. The decisions and algorithms of the Scientific Committee of the Ministry of Health guided us. All branches, especially department of emergency, internal diseases, intensive care, radiology, family medicine, clinical microbiology, have made important contributions in patient monitoring and management. Multidisciplinary cooperation in patient management and combating the infectious disease has enabled us to make an important institutional contributions to healthcare in this challenging period.