Original Article

The Relationship of Multifocality With Prognostic Factors in Renal Cell Carcinoma


  • Tahir Karadeniz
  • Vahit Güzelburç
  • Süleyman Şahin
  • Hüseyin Beşiroğlu

Received Date: 05.07.2011 Accepted Date: 13.09.2011 Eur Arc Med Res 2012;28(1):35-41


This study focuses on patient selection for nephron-sparing surgery, indications of which have extended, by analyzing the multifocality rate of renal cell carcinoma and its relationship with clinical, anatomical and histological properties of prognostic factors.


294 patients admitted to Istanbul Okmeydanı Training and Research Hospital 2 nd Urology Clinics between May 1996 and February 2010 with a history of radical nephrectomy for renal tumor whose histopathology revealed renal cell carcinoma (RCC) were included in the study. Patients who had undergone nephron-sparing surgery for renal tumor and whose pathology did not reveal RCC were excluded. Preoperative findings and postoperative pathology reports of 294 patients were examined.


Of the patients included in the study, 209 (71.1 %) were male and 85 (28.9 %) were female. The mean largest diameter of the renal tumors was 8, 4±4, 2 cm (1-28 cm). Renal cell tumors were localized in the upper (n=108 patients: 1/3) mid (n=91: 31 %) and lower (n= 95: 32 %) segments of the kidneys. Out of 294 patients who had undergone radical nephrectomy for RCC, histopathology revealed multifocality in 14 (4.76 %) patients. Statistically significant correlation was not observed between multifocality of RCC and sex, laterality, and location of the tumor, tumor diameter, pathologic stage, capsular invasion, lymph node involvement, presence of metastasis, Fuhrman nuclear grading and histologic types of the tumor.


The correlation of multifocality which was searched for to detect recurrence rate of the tumor from another part of the kidney, with prognostic factors analyzed in the study was not statistically significant. We think that nephron-sparing surgery is safe for all RCCs with suitable medical and surgical indications.

Keywords: renal cell carcinoma, radical nephrectomy, nephron-sparing surgery, multifocality