Objective:
We aimed to present the results of cervical biopsy of patients diagnosed as atypical squamous cell abnormality (ASC-H) in PapSmear Test (PST) results, where high-grade squamous intraepithelial lesion can not be excluded.
Material and Methods:
The PST results from 7527 patients who applied to the gynecological oncology polyclinic between 2004 and 2016 were retrospectively reviewed. The results of colposcopy, cervical biopsy, and Loop Electrosurgical Excision Procedure (LEEP) and cold conization were evaluated for 201 patients diagnosed as ASC-H for diagnostic purposes.
Results:
Of the 7527 patients who underwent PST, 201 (2.6%) were diagnosed as cervical cytology ASC-H. The colposcopy and punch biopsy results of 197 patients were evaluated, 107 (54.3%) patients had no lesions, 38 (19.2%) patients had Cervical Intraepithelial Neoplasia-1 (CIN1), 19 (9.6%) patients had Cervical Intraepithelial Neoplasia-2(CIN2), 22 (11.1%) patients had Cervical Intraepithelial Neoplasia-3 (CIN3), 6 (3%) patients had carcinoma in situ (CIS) and 5 (2.5%) patients had cervical carcinoma. Cervical excisional procedure was performed in 47 (100%) patients with CIN2, CIN3, CIS, in 12 (31.5%) patients with CIN1 and in 14 (13%) patients with the suspicion of malignancy due to the benign pathological results. 50 patients received LEEP and 23 patients received cold salivation. Three patients with biopsy results of CIN3 who underwent excisional procedure were found to have squamous cell carcinoma as a result of cold conization.
Conclusion:
We conclude that colposcopy and cervical biopsy of these patients are important for the detection of preinvasive lesions, because 26.3% of the ASCH patients in the PST have a high CIN-2 or higher lesion and high Human Papilloma Virus (HPV) positivity.
Keywords: ASC-H, cervical intraepithelial neoplasia, cervical biopsy