The Liver involvement in syphilis patients is rare and varies according to the stage of the disease. Despite marked elevations of the liver enzymes are usually no visible jaundice. In this paper, we presented cholestatic hepatitis in a patient with secondary stage syhilis. A 63 year old male patient was presented to our clinic with complaints fever, rash, myalgia, arthralgia, anorexia, weight loss, widespread rash on the body, cough, and night sweats. It was learned rash complaint of the patient had been started two days ago, other complaints continued for three weeks. On physical examination, fever was 38.1°C, maculopapular rash on the all body, cervical and inguinal lymphadenopathies, hepatomegaly, hepatomegali with painful by palpation on the right upper quadrant. On Laboratory findings, liver enzymes were highly determined. Diagnostic tests for syphilis, VDRL 1/32 and TPHA 1/1280 titer were positive. Markers of viral hepatitis were negative. We diagnosed as syphilis and a single dose of penicillin G benzathine were given. The clinical signs of the patient improved a week later and liver function tests were normal three weeks later. We think that syphilis group should be considered in the differential diagnosis of cholestatic hepatitis.
Keywords: Cholestatic hepatitis, secondary stage syphilis, rash